Myeloid-derived suppressor cells: Implication in myeloid malignancies and immunotherapy.
Acta Histochem
; 126(5-7): 152183, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39029317
ABSTRACT
Myeloid malignancies stem from a modified hematopoietic stem cell and predominantly include acute myeloid leukemia, myelodysplastic neoplasms, myeloproliferative malignancies, and chronic myelomonocytic leukemia. Myeloid-derived suppressor cells (MDSCs) exhibit immunoregulatory properties by governing the innate and adaptive immune systems, creating a permissive and supportive environment for neoplasm growth. This review examines the key characteristics of MDSCs in myeloid malignancies, highlighting that an increased MDSC count corresponds to heightened immunosuppressive capabilities, fostering an immune-tolerant neoplasm microenvironment. Also, this review analyzes and describes the potential of combined cancer therapies, focusing on targeting MDSC generation, expansion, and their inherent immunosuppressive activities to enhance the efficacy of current cancer immunotherapies. A comprehensive understanding of the implications of myeloid malignancies may enhance the exploration of immunotherapeutic strategies for their potential application.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microambiente Tumoral
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Células Supressoras Mieloides
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Imunoterapia
Limite:
Animals
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Humans
Idioma:
En
Revista:
Acta Histochem
/
Acta histochem. (Print)
/
Acta histochemica (Print)
Ano de publicação:
2024
Tipo de documento:
Article