Loss of Tob1 promotes muscle regeneration through muscle stem cell expansion.
J Cell Sci
; 137(15)2024 08 01.
Article
em En
| MEDLINE
| ID: mdl-39037211
ABSTRACT
Muscle stem cells (MuSCs) play an indispensable role in postnatal muscle growth and hypertrophy in adults. MuSCs also retain a highly regenerative capacity and are therefore considered a promising stem cell source for regenerative therapy for muscle diseases. In this study, we identify tumor-suppressor protein Tob1 as a Pax7 target protein that negatively controls the population expansion of MuSCs. Tob1 protein is undetectable in the quiescent state but is upregulated during activation in MuSCs. Tob1 ablation in mice accelerates MuSC population expansion and boosts muscle regeneration. Moreover, inactivation of Tob1 in MuSCs ameliorates the efficiency of MuSC transplantation in a murine muscular dystrophy model. Collectively, selective targeting of Tob1 might be a therapeutic option for the treatment of muscular diseases, including muscular dystrophy and age-related sarcopenia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Células-Tronco
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Músculo Esquelético
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Fator de Transcrição PAX7
Limite:
Animals
Idioma:
En
Revista:
J Cell Sci
/
J. cell. sci
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Journal of cell science
Ano de publicação:
2024
Tipo de documento:
Article