Association between the IL1B-511 C>T polymorphism and the risk of hematologic malignancies: data from a meta-analysis.
Cancer Biol Ther
; 25(1): 2382503, 2024 Dec 31.
Article
em En
| MEDLINE
| ID: mdl-39039694
ABSTRACT
The relationship between the IL1B-511C>T (rs16944) polymorphism and the risk of developing hematologic malignancies remains controversial. Thus, we performed a meta-analysis to evaluate the association between IL1B-511C>T polymorphism and the risk of developing hematologic malignancies. A comprehensive search was conducted to identify all eligible studies on IL1B-511C>T polymorphism and hematologic malignancies. Twelve case-control studies, with 2,896 cases and 3,716 controls, were selected for the analysis. The overall data failed to indicate a significant association between IL1B-511C>T polymorphism and the risk of hematologic malignancies (OR1.06, 95% Confidence Interval [CI] 0.93-1.22). Moreover, non-significant associations were observed in a stratified analysis according to neoplasm type (multiple myeloma, Hodgkin's lymphoma, and non-Hodgkin's lymphoma), ethnicity (European and Asian), and Hardy-Weinberg equilibrium. In summary, our results suggest that there is no association between the IL1B-511C>T polymorphism and the risk of hematologic malignancies. As such, further large-scale studies are needed to confirm our findings.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hematológicas
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Interleucina-1beta
Limite:
Humans
Idioma:
En
Revista:
Cancer Biol Ther
Ano de publicação:
2024
Tipo de documento:
Article