The effect of dapagliflozin ointment on induced psoriasis in an experimental model.
J Med Life
; 17(3): 281-285, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-39044933
ABSTRACT
Dapagliflozin is a pharmacological drug commonly used to manage type 2 diabetes by inhibiting the sodium-glucose cotransporter in the proximal renal tubules. The primary objective of this research was to develop a topical ointment formulation containing dapagliflozin and assess its efficacy in treating psoriasis using an imiquimod-induced psoriasis model. A total of 16 Swiss albino mice, with weights ranging from 24 to 30 grams, were allocated randomly into six groups, each group including ten animals. The study assessed the effects of various concentrations of dapagliflozin ointment on levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), IL-17, and IL-37, as well as on erythema, scaling, and epidermal thickness. Dapagliflozin ointment significantly reduced these cytokine levels and disease scores, indicating anti-psoriatic and anti-inflammatory properties. Therefore, when applied topically, dapagliflozin ointment had strong efficacy against imiquimod-induced psoriatic skin inflammation, suggesting its potential as a novel therapeutic option for psoriasis treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pomadas
/
Psoríase
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Compostos Benzidrílicos
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Modelos Animais de Doenças
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Imiquimode
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Glucosídeos
Limite:
Animals
Idioma:
En
Revista:
J Med Life
Ano de publicação:
2024
Tipo de documento:
Article