Your browser doesn't support javascript.
loading
Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes.
Schmidt, Thomas L; Endersby-Harshman, Nancy M; van Rooyen, Anthony R J; Katusele, Michelle; Vinit, Rebecca; Robinson, Leanne J; Laman, Moses; Karl, Stephan; Hoffmann, Ary A.
Afiliação
  • Schmidt TL; Bio21 Institute, School of BioSciences, University of Melbourne, Parkville, Australia. toms@unimelb.edu.au.
  • Endersby-Harshman NM; Bio21 Institute, School of BioSciences, University of Melbourne, Parkville, Australia.
  • van Rooyen ARJ; Cesar Australia, Brunswick, Victoria, Australia.
  • Katusele M; PNG Institute of Medical Research, Madang, Madang Province, Papua New Guinea.
  • Vinit R; PNG Institute of Medical Research, Madang, Madang Province, Papua New Guinea.
  • Robinson LJ; PNG Institute of Medical Research, Madang, Madang Province, Papua New Guinea.
  • Laman M; Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland, Australia.
  • Karl S; PNG Institute of Medical Research, Madang, Madang Province, Papua New Guinea.
  • Hoffmann AA; Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, Queensland, Australia.
Nat Commun ; 15(1): 6251, 2024 Jul 24.
Article em En | MEDLINE | ID: mdl-39048545
ABSTRACT
Aedes aegypti (yellow fever mosquito) and Ae. albopictus (Asian tiger mosquito) are globally invasive pests that confer the world's dengue burden. Insecticide-based management has led to the evolution of insecticide resistance in both species, though the genetic architecture and geographical spread of resistance remains incompletely understood. This study investigates partial selective sweeps at resistance genes on two chromosomes and characterises their spread across populations. Sweeps at the voltage-sensitive sodium channel (VSSC) gene on chromosome 3 correspond to one resistance-associated nucleotide substitution in Ae. albopictus and three in Ae. aegypti, including two substitutions at the same nucleotide position (F1534C) that have evolved and spread independently. In Ae. aegypti, we also identify partial sweeps at a second locus on chromosome 2. This locus contains 15 glutathione S-transferase (GST) epsilon class genes with significant copy number variation among populations and where three distinct genetic backgrounds have spread across the Indo-Pacific region, the Americas, and Australia. Local geographical patterns and linkage networks indicate VSSC and GST backgrounds probably spread at different times and interact locally with different genes to produce resistance phenotypes. These findings highlight the rapid global spread of resistance and are evidence for the critical importance of GST genes in resistance evolution.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência a Inseticidas / Aedes Limite: Animals Idioma: En Revista: Nat Commun Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência a Inseticidas / Aedes Limite: Animals Idioma: En Revista: Nat Commun Ano de publicação: 2024 Tipo de documento: Article