Handedness in Alzheimer's disease: A systematic review.
Brain Res
; 1840: 149131, 2024 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-39053686
ABSTRACT
Handedness has traditionally been employed as a proxy of brain lateralization in research. Alzheimer's disease (AD) manifests as a neurodegenerative disorder characterized by impairments across various neuropsychological functions, including visuospatial and language, many of which exhibit lateralization in the human brain. While previous studies have investigated the relationship between AD and handedness, findings have been inconsistent. This article aims to provide an up-to-date overview of studies investigating hand preference in AD and the subtypes, specifically early- and late-onset AD. Through a synthesis of these studies, we conclude that handedness currently lacks utility as a diagnostic biomarker for AD and its subtypes, and this is further supported by the meta-analytic results based on data from over 10,000 AD patients. We emphasize the necessity for future research endeavors, particularly those leveraging advanced neuroimaging techniques to explore the role of brain asymmetry in AD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Doença de Alzheimer
/
Lateralidade Funcional
Limite:
Humans
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2024
Tipo de documento:
Article