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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations.
Wang, Yiying; Le, Yuan; Harris, Kelly L; Chen, Ying; Li, Xilin; Faske, Jennifer; Wynne, Rebecca A; Mittelstaedt, Roberta A; Cao, Xuefei; Miranda-Colon, Jaime; Elkins, Lana; Muskhelishvili, Levan; Davis, Kelly; Mei, Nan; Sun, Wei; Robison, Timothy W; Heflich, Robert H; Parsons, Barbara L.
Afiliação
  • Wang Y; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: yiying.wang@fda.hhs.gov.
  • Le Y; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Harris KL; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Chen Y; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Li X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Faske J; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Wynne RA; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Mittelstaedt RA; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Cao X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Miranda-Colon J; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Elkins L; Toxicologic Pathology Associates, Jefferson, AR 72079, USA.
  • Muskhelishvili L; Toxicologic Pathology Associates, Jefferson, AR 72079, USA.
  • Davis K; Toxicologic Pathology Associates, Jefferson, AR 72079, USA.
  • Mei N; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Sun W; Division of Pharmacology/Toxicology for Immunology & Inflammation, Office of Immunology and Inflammation, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.
  • Robison TW; Division of Pharmacology/Toxicology for Immunology & Inflammation, Office of Immunology and Inflammation, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.
  • Heflich RH; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
  • Parsons BL; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Mutat Res Genet Toxicol Environ Mutagen ; 897: 503786, 2024 Jul.
Article em En | MEDLINE | ID: mdl-39054009
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Metanossulfonato de Etila / Mutação Limite: Humans Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Metanossulfonato de Etila / Mutação Limite: Humans Idioma: En Revista: Mutat Res Genet Toxicol Environ Mutagen Ano de publicação: 2024 Tipo de documento: Article