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Vitacrystallography: Structural Biomarkers of Breast Cancer Obtained by X-ray Scattering.
Denisov, Sergey; Blinchevsky, Benjamin; Friedman, Jonathan; Gerbelli, Barbara; Ajeer, Ash; Adams, Lois; Greenwood, Charlene; Rogers, Keith; Mourokh, Lev; Lazarev, Pavel.
Afiliação
  • Denisov S; Matur UK Ltd., 5 New Street Square, London EC4A 3TW, UK.
  • Blinchevsky B; Institut de Chimie Physique, UMR8000, CNRS, Université Paris-Saclay, Bât. 349, 91405 Orsay, France.
  • Friedman J; Matur UK Ltd., 5 New Street Square, London EC4A 3TW, UK.
  • Gerbelli B; EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA.
  • Ajeer A; EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA.
  • Adams L; Physics Department, Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY 11367, USA.
  • Greenwood C; School of Chemical and Physical Sciences, Keele University, Keele ST5 5BG, UK.
  • Rogers K; School of Chemical and Physical Sciences, Keele University, Keele ST5 5BG, UK.
  • Mourokh L; School of Chemical and Physical Sciences, Keele University, Keele ST5 5BG, UK.
  • Lazarev P; EosDx, Inc., 1455 Adams Drive, Menlo Park, CA 94025, USA.
Cancers (Basel) ; 16(14)2024 Jul 09.
Article em En | MEDLINE | ID: mdl-39061139
ABSTRACT
With breast cancer being one of the most widespread causes of death for women, there is an unmet need for its early detection. For this purpose, we propose a non-invasive approach based on X-ray scattering. We measured samples from 107 unique patients provided by the Breast Cancer Now Tissue Biobank, with the total dataset containing 2958 entries. Two different sample-to-detector distances, 2 and 16 cm, were used to access various structural biomarkers at distinct ranges of momentum transfer values. The biomarkers related to lipid metabolism are consistent with those of previous studies. Machine learning analysis based on the Random Forest Classifier demonstrates excellent performance metrics for cancer/non-cancer binary decisions. The best sensitivity and specificity values are 80% and 92%, respectively, for the sample-to-detector distance of 2 cm and 86% and 83% for the sample-to-detector distance of 16 cm.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2024 Tipo de documento: Article