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Can Hematological Inflammatory Indices Be Used to Differentiate Modic Type 1 Changes from Brucella Spondylodiscitis?
Sah, Volkan; Baran, Ali Irfan.
Afiliação
  • Sah V; Department of Sports Medicine, Medical Faculty, Van Yüzüncü Yil University, Van 65090, Turkey.
  • Baran AI; Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Van Yüzüncü Yil University, Van 65090, Turkey.
Medicina (Kaunas) ; 60(7)2024 Jul 14.
Article em En | MEDLINE | ID: mdl-39064560
ABSTRACT
Background and

Objectives:

Differentiation between brucella spondylodiscitis and Modic type I changes (MC1) includes difficulties. Hematological inflammatory indices (HII) such as neutrophil to lymphocyte ratio (NLR) and aggregate index of systemic inflammation (AISI) are suggested as indicators of inflammation and infection and have diagnostic, prognostic, and predictive roles in various diseases. This study aimed to evaluate differences between brucella spondylodiscitis and MC1 in terms of HII. Materials and

Methods:

Thirty-five patients with brucella spondylodiscitis and thirty-seven with MC1 were enrolled in the study. Brucella spondylodiscitis and MC1 were diagnosed by microbiological, serological, and radiological diagnostic tools. HII (NLR, MLR, PLR, NLPR, SII, SIRI, AISI) were derived from baseline complete blood count.

Results:

The two groups were similar for age (p = 0.579) and gender (p = 0.092), leukocyte (p = 0.127), neutrophil (p = 0.366), lymphocyte (p = 0.090), and monocyte (p = 0.756) scores. The Brucella spondylodiscitis group had significantly lower pain duration (p < 0.001), higher CRP and ESR levels (p < 0.001), and lower platelet count (p = 0.047) than the MC1 group. The two groups had similarity in terms of HII NLR (p = 0.553), MLR (p = 0.294), PLR (p = 0.772), NLPR (p = 0.115), SII (p = 0.798), SIRI (p = 0.447), and AISI (p = 0.248).

Conclusions:

Increased HII can be used to differentiate infectious and non-infectious conditions, but this may be invalid in brucellosis. However, pain duration, CRP and ESR levels, and platelet count may be useful to distinguish brucella spondylodiscitis from MC1.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Brucelose / Discite Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Brucelose / Discite Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicina (Kaunas) Ano de publicação: 2024 Tipo de documento: Article