Causal Relationship Between Obstructive Sleep Apnea and Temporomandibular Disorders: A Bidirectional Mendelian Randomization Analysis.
Nat Sci Sleep
; 16: 1045-1052, 2024.
Article
em En
| MEDLINE
| ID: mdl-39076457
ABSTRACT
Objective:
This study was conducted to investigate the bidirectional causal relationship between obstructive sleep apnea (OSA) and temporomandibular disorders (TMD).Methods:
Using an online pooled dataset of genome-wide association studies (GWAS), a two-sample bi-directional Mendelian randomization (MR) method was implemented. Inverse variance weighting was used as the primary analyses approach, and other methods of MR Egger, weighted median method, MR-Egger, Simple mode, and Weighted mode analysis were conducted as supplements to evaluate the causal relationship between OSA and TMD with odds ratios (OR) and 95% confidence interval (CI). Furthermore, the Cochran Q, MR-Egger, and MR-PRESSO approaches were used to perform the heterogeneity test and multiple validity.Results:
The general results of the forward MR analysis indicated that OSA had a significant causal influence on TMD (OR=1.241, 95% CI 1.009-1.526, P=0.041), but no significant correlation was observed in the reverse MR analysis (IVW OR=0.975, 95% CI=0.918-1.036, P=0.411).Conclusion:
In summary, our research demonstrated a hereditary causative relationship between OSA and TMD, indicating that appropriate intervention is required for both prevention and treatment of TMD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Nat Sci Sleep
Ano de publicação:
2024
Tipo de documento:
Article