Cancer phototherapy by CO releasing terpyridine-based Re(I) tricarbonyl complexes via ROS generation and NADH oxidation.
Dalton Trans
; 53(32): 13591-13601, 2024 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-39078263
ABSTRACT
Here, we have synthesized and characterized three visible light responsive terpyridine based-Re(I)-tricarbonyl complexes; [Re(CO)3(ph-tpy)Cl] (Retp1), [Re(CO)3(an-tpy)Cl] (Retp2), and [Re(CO)3(py-tpy)Cl] (Retp3) where ph-tpy = 4'-phenyl-2,2'6',2â³-terpyridine; an-tpy = 4'-anthracenyl-2,2'6',2â³-terpyridine, py-tpy = 4'-pyrenyl-2,2'6',2â³-terpyridine. The structures of Retp1 and Retp2 were confirmed from the SC-XRD data, indicating distorted octahedral structures. Unlike traditional PDT agents, these complexes generated reactive oxygen species (ROS) via type I and type II pathways and oxidized redox crucial NADH (reduced nicotinamide adenine dinucleotide) upon visible light exposure. Retp3 showed significant mitochondrial localization and demonstrated photoactivated anticancer activity (IC50 â¼ 2 µM) by inducing ROS-mediated cell death in cancer cells selectively (photocytotoxicity Index, PI > 28) upon compromising mitochondrial function in A549 cells. Their diagnostic capabilities were ultimately assessed using clinically relevant 3D multicellular tumor spheroids (MCTs).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredução
/
Piridinas
/
Rênio
/
Espécies Reativas de Oxigênio
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Complexos de Coordenação
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NAD
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Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Dalton Trans
Ano de publicação:
2024
Tipo de documento:
Article