Pallidal and Thalamic Deep Brain Stimulation in the Treatment of Unilateral Dystonia: A Prospective Assessment.
Mov Disord Clin Pract
; 2024 Aug 02.
Article
em En
| MEDLINE
| ID: mdl-39092579
ABSTRACT
BACKGROUND:
The complexities of unilateral dystonia have led to exploring simultaneous (dual) globus pallidus internus (GPi) and motor ventral thalamus (Vim/Vop) deep brain stimulation (DBS), yet detailed assessments are lacking.OBJECTIVES:
To assess the efficacy of GPi, Vim/Vop, and dual DBS in unilateral dystonia.METHODS:
Three patients with unilateral dystonia (two idiopathic, one acquired), implanted with two DBS electrodes targeting ipsilateral Vim/Vop and GPi, were included. Three stimulation modalities were assessed. First, one electrode was activated, then the other, and finally, both electrodes were activated simultaneously.RESULTS:
DBS yielded substantial symptomatic reductions in all three evaluated stimulation modalities. Patients exhibited varying responses regarding quality-of-life and depressive symptoms. Treatment satisfaction didn't align with clinical improvements, potentially affected by unrealistic expectations.CONCLUSIONS:
This study contributes critical insights into GPi, Vim/Vop and simultaneous stimulation for unilateral dystonia. The safety of the procedure underscores the promise of this approach.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mov Disord Clin Pract
/
Mov. disord. clin. pract
/
Movement disorders clinical practice
Ano de publicação:
2024
Tipo de documento:
Article