Use of Adjuvant Compositions Based on Squalene Ensures Induction of Neutralizing Antibodies against SARS-CoV-2.
Bull Exp Biol Med
; 177(2): 221-224, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-39093475
ABSTRACT
Squalene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the developed squalene-based compositions in combination with RBD allows obtaining high titers of specific antibodies from 105 to 2×106. The blood sera from immunized mice exhibit neutralizing activity against SARS-CoV-2 Delta variant (B.1.617.2) with a titer up to 12000.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esqualeno
/
Adjuvantes Imunológicos
/
Anticorpos Neutralizantes
/
Glicoproteína da Espícula de Coronavírus
/
SARS-CoV-2
/
COVID-19
/
Anticorpos Antivirais
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Bull Exp Biol Med
/
Bull. exp. biol. med
/
Bulletin of experimental biology and medicine
Ano de publicação:
2024
Tipo de documento:
Article