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Insights into bacterial metabolism from small RNAs.
Papenfort, Kai; Storz, Gisela.
Afiliação
  • Papenfort K; Friedrich Schiller University Jena, Institute of Microbiology, 07745 Jena, Germany; Microverse Cluster, Friedrich Schiller University Jena, 07743 Jena, Germany. Electronic address: kai.papenfort@uni-jena.de.
  • Storz G; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-4417, USA. Electronic address: storzg@mail.nih.gov.
Cell Chem Biol ; 31(9): 1571-1577, 2024 Sep 19.
Article em En | MEDLINE | ID: mdl-39094580
ABSTRACT
The study of small, regulatory RNAs (sRNA) that act by base-pairing with target RNAs in bacteria has been steadily advancing, particularly with the availability of more and more transcriptome and RNA-RNA interactome datasets. While the characterization of multiple sRNAs has helped to elucidate their mechanisms of action, these studies also are providing insights into protein function, control of metabolic flux, and connections between metabolic pathways as we will discuss here. In describing several examples of the metabolic insights gained, we will summarize the different types of base-pairing sRNAs including mRNA-derived sRNAs, sponge RNAs, RNA mimics, and dual-function RNAs as well as suggest how information about sRNAs could be exploited in the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / RNA Bacteriano / Pequeno RNA não Traduzido Idioma: En Revista: Cell Chem Biol Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / RNA Bacteriano / Pequeno RNA não Traduzido Idioma: En Revista: Cell Chem Biol Ano de publicação: 2024 Tipo de documento: Article