R2Dtool: integration and visualization of isoform-resolved RNA features.
Bioinformatics
; 40(8)2024 Aug 02.
Article
em En
| MEDLINE
| ID: mdl-39110520
ABSTRACT
MOTIVATION Long-read RNA sequencing enables the mapping of RNA modifications, structures, and protein-interaction sites at the resolution of individual transcript isoforms. To understand the functions of these RNA features, it is critical to analyze them in the context of transcriptomic and genomic annotations, such as open reading frames and splice junctions. RESULTS:
We have developed R2Dtool, a bioinformatics tool that integrates transcript-mapped information with transcript and genome annotations, allowing for the isoform-resolved analytics and graphical representation of RNA features in their genomic context. We illustrate R2Dtool's capability to integrate and expedite RNA feature analysis using epitranscriptomics data. R2Dtool facilitates the comprehensive analysis and interpretation of alternative transcript isoforms. AVAILABILITY AND IMPLEMENTATION R2Dtool is freely available under the MIT license at github.com/comprna/R2Dtool.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Análise de Sequência de RNA
Limite:
Humans
Idioma:
En
Revista:
Bioinformatics
Ano de publicação:
2024
Tipo de documento:
Article