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What goes up must come down: off switches for regulatory RNAs.
McJunkin, Katherine; Gottesman, Susan.
Afiliação
  • McJunkin K; Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, Maryland 20892, USA; gottesms@nih.gov katherine.mcjunkin@nih.gov.
  • Gottesman S; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA gottesms@nih.gov katherine.mcjunkin@nih.gov.
Genes Dev ; 38(13-14): 597-613, 2024 Aug 20.
Article em En | MEDLINE | ID: mdl-39111824
ABSTRACT
Small RNAs base pair with and regulate mRNA translation and stability. For both bacterial small regulatory RNAs and eukaryotic microRNAs, association with partner proteins is critical for the stability and function of the regulatory RNAs. We review the mechanisms for degradation of these RNAs displacement of the regulatory RNA from its protein partner (in bacteria) or destruction of the protein and its associated microRNAs (in eukaryotes). These mechanisms can allow specific destruction of a regulatory RNA via pairing with a decay trigger RNA or function as global off switches by disrupting the stability or function of the protein partner.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estabilidade de RNA / MicroRNAs Limite: Animals / Humans Idioma: En Revista: Genes Dev Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estabilidade de RNA / MicroRNAs Limite: Animals / Humans Idioma: En Revista: Genes Dev Ano de publicação: 2024 Tipo de documento: Article