Wnt/ß-catenin signaling in corneal epithelium development, homeostasis, and pathobiology.
Exp Eye Res
; 246: 110022, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39117134
ABSTRACT
The corneal epithelium is located on the most anterior surface of the eyeball and protects against external stimuli. The development of the corneal epithelium and the maintenance of corneal homeostasis are essential for the maintenance of visual acuity. It has been discovered recently via the in-depth investigation of ocular surface illnesses that the Wnt/ß-catenin signaling pathway is necessary for the growth and stratification of corneal epithelial cells as well as the control of endothelial cell stability. In addition, the Wnt/ß-catenin signaling pathway is directly linked to the development of common corneal illnesses such as keratoconus, fungal keratitis, and corneal neovascularization. This review mainly summarizes the role of the Wnt/ß-catenin signaling pathway in the development, homeostasis, and pathobiology of cornea, hoping to provide new insights into the study of corneal epithelium and the treatment of related diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epitélio Corneano
/
Via de Sinalização Wnt
/
Homeostase
Limite:
Animals
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Humans
Idioma:
En
Revista:
Exp Eye Res
Ano de publicação:
2024
Tipo de documento:
Article