COMPLICATIONS OF INTRAOSSEOUS ADMINISTRATION OF VANCOMYCIN IN TOTAL HIP ARTHROPLASTY. / COMPLICACIONES DE LA ADMINISTARCION INTRAOSEA DE VANCOMICINA EN ARTROPLASTIA TOTAL DE CADERA.

ABSTRACT

INTRODUCTION: The incidence of periprosthetic joint infection (PJI) in hip surgeries has significantly decreased thanks to intravenous antibiotic prophylaxis. However, in patients colonized with methicillin-resistant Staphylococcus aureus (MRSA) or those at risk of colonization, it is necessary to include vancomycin in the prophylaxis. Intraosseous (IO) administration of vancomycin could enhance its effectiveness in total hip arthroplasty (THA). MATERIALS AND METHODS: A retrospective study was conducted between March and December 2023 involving 53 patients scheduled for primary THA with colonization risk factors. The median age of the patients was 67 years (range 61 to 75), and all received treatment with intraosseous vancomycin (500 mg). Detailed records and documentation of complications during hospitalization and the first three months post-surgery were maintained. As a secondary outcome measure, the incidence of PJI was explored. RESULTS: We administered 500 mg of intraosseous vancomycin, injected into the greater trochanter, along with standard intravenous (IV) prophylaxis. The incidence of complications was 1.64%. The periprosthetic joint infection rate at 90 days was 0%. CONCLUSIONS: Intraosseous administration of low-dose vancomycin in total hip arthroplasty for patients at risk of MRSA colonization, combined with standard IV prophylaxis, was shown to be safe and did not present significant adverse effects. Furthermore, this strategy eliminates the logistical challenges associated with timely vancomycin administration. LEVEL OF EVIDENCE IV Case Series.