Superficial Atypical Lipomatous Tumor With Pleomorphic Features: Case Report and Discussion of the Literature.
Am J Dermatopathol
; 46(8): 509-511, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39133219
ABSTRACT
ABSTRACT Among liposarcomas, well-differentiated liposarcoma and dedifferentiated liposarcoma are the most common. The majority of these tumors are found in deep retroperitoneum or extremities. When found outside the retroperitoneum, these adipose-derived tumors are known as atypical lipomatous tumors (ALT). Superficial ALT are particularly rare; thus, little is known about their clinical presentation, genomic status, and management. Here, we present the case of a 54-year-old man with an intermittently bothersome, slowly growing mass on his left upper back for over 2 years, which was incidentally diagnosed as ALT. This patient's ALT, however, showed a profound degree of pleomorphism with MDM2 and control centromere 12 (CEP12) coamplification and negative CD34 and S100 and RB1 expression, unlike most other ALT described in the literature. This case report details the diagnostic workup and histopathological findings for adipose tumors and summarizes the different subtypes, including atypical spindle cell/pleomorphic lipomatous tumor, pleomorphic liposarcoma, and spindle cell/pleomorphic lipoma, with brief discussion on management.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lipossarcoma
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Dermatopathol
Ano de publicação:
2024
Tipo de documento:
Article