[Sarcopenia and immune-related toxicity in patients with malignant melanoma undergoing immune checkpoint inhibition]. / Die Bedeutung von Sarkopenie für die immunvermittelte Toxizität bei Patienten mit malignem Melanom unter einer Immuncheckpoint-Inhibition.
Dermatologie (Heidelb)
; 75(10): 798-803, 2024 Oct.
Article
em De
| MEDLINE
| ID: mdl-39143426
ABSTRACT
BACKGROUND AND OBJECTIVES:
Sarcopenia is the generalized loss of muscle strength, mass, and function. The aim was to investigate whether pretherapeutic sarcopenia, as determined by the psoas muscles, affects therapy-mediated toxicity in patients with malignant melanoma undergoing immunotherapy. PATIENTS ANDMETHODS:
Measurement of psoas musculature was performed pretherapeutically using computed tomography at the level of the third lumbar vertebra in the axial plane in 75 patients between January 2011 and December 2020. Sarcopenia was defined using the psoas muscle index (PMI). Immune-related toxicity was retrospectively assessed.RESULTS:
Treatment-related toxicity was recorded in 33 of the 75 patients (44%). Of these, 16 patients (36.2%) experienced dose-limiting severe events (DLT). Pretherapeutic sarcopenia was identified in 25 patients (33.3%). Comparative analysis showed that the patients with a DLT had lower PMI values compared with the patient group without a DLT (4.65⯱ 1.33 vs. 5.79⯱ 1.67â¯cm2m-2, pâ¯= 0.015) (odds ratioâ¯= 0.60, 95% confidence interval 0.40-0.92, pâ¯= 0.02).CONCLUSIONS:
Pretherapeutic sarcopenia measured based on the psoas muscle is not a significant predictor of immune-mediated toxicity in patients with malignant melanoma treated with immune checkpoint inhibitors. Patients with DLT have lower values for the psoas muscle parameters PMI compared to the group of patients without DLT.Palavras-chave
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Músculos Psoas
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Sarcopenia
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Inibidores de Checkpoint Imunológico
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Melanoma
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
De
Revista:
Dermatologie (Heidelb)
Ano de publicação:
2024
Tipo de documento:
Article