[Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review]. / Geschlechtsspezifische Unterschiede in der Entwicklung kolorektaler Karzinome bei Lynch-Syndrom-Betroffenen ein systematisches Review.
Chirurgie (Heidelb)
; 95(9): 696-708, 2024 Sep.
Article
em De
| MEDLINE
| ID: mdl-39145869
ABSTRACT
BACKGROUND:
Lynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented.OBJECTIVE:
This systematic review aims to investigate gender-specific differences in CRC development among LS patients. MATERIAL ANDMETHODS:
A systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria.RESULTS:
Men have a higher risk of CRC and develop CRC earlier compared to women.CONCLUSION:
These findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Neoplasias Colorretais Hereditárias sem Polipose
Limite:
Female
/
Humans
/
Male
Idioma:
De
Revista:
Chirurgie (Heidelb)
Ano de publicação:
2024
Tipo de documento:
Article