Diversified Reactivity of Triphenylphosphine: Reinvestigation of the Phosphine-Mediated Reductive Condensation Approach for the Synthesis of Substituted Furans.
J Org Chem
; 2024 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-39151054
ABSTRACT
A reinvestigation of "Phosphine-Mediated Reductive Condensation of γ-Acyloxy Butynoates A Diversity Oriented Strategy for the Construction of Substituted Furans" (J. Am. Chem. Soc. 2004, 126, 4118-4119) revealed different chemoselectivity of triphenylphosphine in the reactions with the γ-acyloxy butynoate substrates of varying substitution patterns/electronics. Furthermore, the electronics of the triaryl phosphine reagent could be tuned to trap a putative intermediate such as A, leading to the semihydrogenation of propiolamide substrates.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2024
Tipo de documento:
Article