Iodine-mediated decarboxylative coupling to synthesize ß-sulfonyl-ene-amines/2,3-diarythio-pyrroles from α-amino acids and sodium sulfinates.
Org Biomol Chem
; 22(36): 7321-7326, 2024 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-39171619
ABSTRACT
A novel process has been developed for the selective synthesis of ß-sulfonyl-enamines and 2,3-diarylthiopyrroles. This process utilizes the decarboxylative coupling and ß-C(sp3)-H functionalization of α-amino acids. In this reaction, iodine functions dually as a tandem catalyst to initiate the decarboxylation of α-amino acids and as an oxidant to facilitate the formation of organic sulfides. This innovative approach not only simplifies the synthesis but also enhances the yield and selectivity of the desired products.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2024
Tipo de documento:
Article