Hematological, inflammatory and serological responses among COVID-19 patients admitted to intensive care unit.

ABSTRACT

Aim: To correlate hematological, inflammatory indicators and serological responses among COVID-19 patients to point out the significant biomarkers for disease management and prognosis.Materials & methods: Standard analytical and molecular methods were used to assess various inflammatory and serological Responses among COVID-19 patients (ICU- (n = 99) and non-ICU patients (n = 64) as compared with health control (n = 40).Results: Significant differences in the Hb, WBC, Lymphocyte count, CRP and serum ferritin (p < 0.05) were observed. Patients' IgM/IgG antibodies against SARS-CoV-2 were associated with increased CRP, LDH and serum ferritin levels.Conclusion: A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission.

This study aimed to find the best biomarkers among COVID-19 patients to be used as indicators of patient eligibility for admission to the intensive care unit and for evaluating the disease complications and proper intervention before cases deteriorated. For the COVID-19 as compared with healthy individuals, results showed significant differences in many hematological indicators such as hemoglobin level, white blood cells and Lymphocyte count. Results also showed a strong correlation between certain serum antibody levels against COVID-19 and admission to intensive care unit.