Highly Sensitized Patients Listed for Heart After Liver Transplantation With or Without Domino.
J Heart Lung Transplant
; 2024 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-39222736
ABSTRACT
For patients with end stage heart disease and borderline hemodynamics, high HLA allosensitization presents a barrier for heart transplantation in a timely manner. Conventional desensitization protocols are inadequate in this context due to time constraints and for the most highly reactive immunologically. We previously reported performing heart after liver transplant with domino liver transplant (HALT-D) on a single patient without liver disease. We describe this patient's course to date as well as four subsequent patients listed for this novel therapy. This experience demonstrates that the liver effectively confers immunoprotection to the heart for patients with high-titer, preformed antibodies. This strategy may provide some measure of equity for demographic groups previously disadvantaged for heart transplantation due to allosensitization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Heart Lung Transplant
Ano de publicação:
2024
Tipo de documento:
Article