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Does the kynurenine pathway play a pathogenic role in autism spectrum disorder?
Santana-Coelho, Danielle.
Afiliação
  • Santana-Coelho D; Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX, USA.
Brain Behav Immun Health ; 40: 100839, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39263315
ABSTRACT
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication, sociability, and repetitive/stereotyped behavior. The etiology of autism is diverse, with genetic susceptibility playing an important role alongside environmental insults and conditions. Human and preclinical studies have shown that ASD is commonly accompanied by inflammation, and inhibition of the inflammatory response can ameliorate, or prevent the phenotype in preclinical studies. The kynurenine pathway, responsible for tryptophan metabolism, is upregulated by inflammation. Hence, this metabolic route has drawn the attention of investigators across different disciplines such as cancer, immunology, and neuroscience. Over the past decade, studies have identified evidence that the kynurenine pathway is also altered in autism spectrum disorders. In this mini review, we will explore the current status quo of the link between the kynurenine pathway and ASD, shedding light on the compelling but still preliminary evidence of this relationship.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Brain Behav Immun Health Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Brain Behav Immun Health Ano de publicação: 2024 Tipo de documento: Article