Adeno-associated virus mediated gene delivery of Perm1 enhances cardiac contractility in mice.
Am J Physiol Heart Circ Physiol
; 2024 Sep 13.
Article
em En
| MEDLINE
| ID: mdl-39269449
ABSTRACT
Reduced muscle contractility and mitochondrial bioenergetics are the hallmarks of systolic heart failure. There is currently no therapy targeting both. Here, we show that gene delivery of Perm1 via adeno-associated virus (AAV) simultaneously enhances cardiac contractility and mitochondrial biogenesis in C57BL6 mice. Moreover, we found that PERM1 interacts with Troponin C (TnC), a key contractile protein in striated muscle, and that AAV-Perm1 led to upregulation of TnC. This study suggests that gene delivery of Perm1 may be a novel therapeutic approach to treat systolic heart failure by simultaneously restoring cardiac contractility and mitochondrial bioenergetics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Am J Physiol Heart Circ Physiol
Ano de publicação:
2024
Tipo de documento:
Article