Interleukin-1 family cytokines and soluble receptors in hidradenitis suppurativa.
Exp Dermatol
; 33(9): e15179, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39278731
ABSTRACT
Hidradenitis suppurativa (HS) is a chronic skin disease, characterized by clinical inflammation of the hair follicle with the recurrence of abscesses, nodules, and tunnels. Recently, several studies suggested a role of IL-1 family (IL-1F) cytokines in eliciting and sustaining the disease. The aim of this work is to perform a comprehensive analysis of IL-1F cytokines, soluble inhibitors and receptors in a cohort of HS patients not treated with biological agents. Sixteen patients affected by HS and 16 healthy controls were recruited; clinical data were collected and disease severity evaluated by means of the International HS Severity Score System (IHS4). Serum levels of IL-1F cytokines, inhibitors and receptors were measured using a Multiplex Assays. IL-18 and free IL-18 levels were significantly higher in patients vs controls. Among soluble inhibitors, IL-1Ra, IL-1R2 and ST2/IL-1R4 were significantly increased. IL-18, free IL-18 and IL-33 levels are strongly correlated with IHS4. Also the inhibitors IL-1Ra and IL-18BP show a correlation with IHS4. The data obtained in this study confirm the involvement of IL-1F cytokines in mediating the disease and determining its severity and suggest a possible role for IL-18 as novel serum biomarker of active disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
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Hidradenite Supurativa
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Interleucina-18
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Proteína Antagonista do Receptor de Interleucina 1
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Receptores Tipo II de Interleucina-1
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Exp Dermatol
Ano de publicação:
2024
Tipo de documento:
Article