Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions.
Placenta
; 158: 10-13, 2024 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-39312864
ABSTRACT
Transposable elements (TEs) play a crucial role in placental development and dysfunction. Our study examined TE expression in pre-eclampsia (PE) using RNA-seq datasets. We identified differentially expressed TEs and explored the genomic location of the most significant TEs, investigating their possible regulatory roles. Notably, three TEs overlapped with putative enhancer regions, suggesting a potential regulatory impact on gene expression. These findings highlight the regulatory potential of TEs and their importance in placental development, supporting that TE dysregulation may contribute to PE pathogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Placenta
Ano de publicação:
2024
Tipo de documento:
Article