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Exosomal non-coding RNAs (ncRNAs) as potential biomarkers in tumor early diagnosis.
Chang, Jingyue; Zhang, Lingquan; Li, Zeting; Qian, Chungen; Du, Juan.
Afiliação
  • Chang J; School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China.
  • Zhang L; School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China.
  • Li Z; School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China.
  • Qian C; Department of Reagent Research and Development, Shenzhen YHLO Biotech Co., Ltd., Shenzhen 518172, Guangdong, China. Electronic address: chungen_qian@hust.edu.cn.
  • Du J; School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China; The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, China. Electronic address: dujuan@cuhk.edu.cn.
Biochim Biophys Acta Rev Cancer ; 1879(6): 189188, 2024 Sep 21.
Article em En | MEDLINE | ID: mdl-39313040
ABSTRACT
Exosomes, extracellular vesicles carrying a cargo rich in various non-coding RNAs (ncRNAs), have emerged as crucial mediators of intercellular communication. Their stability, abundance, and specificity make exosomal ncRNAs promising candidates for biomarker discovery. The discovery of exosomal ncRNAs has unveiled a novel avenue for the exploration of biomarkers in tumor early diagnosis. This review consolidates current knowledge on the role of exosomal ncRNAs as potential biomarkers in the early detection of various tumors. We provide an overview of recent studies demonstrating the diagnostic potential of exosomal ncRNAs across multiple cancer types, highlighting their sensitivity, specificity, and feasibility for early detection. This review underscores the potential of exosomal ncRNAs as non-invasive biomarkers for early tumor diagnosis, paving the way for improved clinical outcomes through timely intervention and personalized management strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biochim Biophys Acta Rev Cancer Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biochim Biophys Acta Rev Cancer Ano de publicação: 2024 Tipo de documento: Article