Maternal-foetal distribution studies in late pregnancy. I. Distribution of [N-methyl-14C]betaine in tissues of beagle dogs and miniature pigs.
Food Chem Toxicol
; 23(6): 609-14, 1985 Jun.
Article
em En
| MEDLINE
| ID: mdl-4040106
ABSTRACT
[N-Me-14C]Betaine was administered iv as a single dose (5 mg/kg) to pregnant beagle dogs and miniature pigs late in gestation. Two hr after administration of the radiolabel, when the compound was in equilibrium, the dams were killed and the foetuses were removed for determination of the radioactivity in maternal and foetal tissues. Eight litters of dogs (56 foetuses) and four litters of pigs (30 foetuses) were examined. The distribution of betaine in both species showed distinct differences between maternal and foetal tissues, indicating definite placental barriers; the placental distribution factor was estimated to be 52.3% in dogs and 97.8% in pigs. The blood/brain distribution factor was 84.6% in maternal dogs, 89% in maternal pigs, 65.7% in foetal dogs and 0% in foetal pigs. In the dog, maternal liver was the largest depot of the administered betaine, followed by foetal liver. Foetal heart, lung and kidney tissues also incorporated radiolabelled betaine. The highest concentrations of betaine in the pig were found in maternal kidney and liver.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Betaína
/
Feto
/
Troca Materno-Fetal
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
1985
Tipo de documento:
Article