Evaluation of (o)-[77Br]bromohippuran as renal tubular function agent.

van Aswegen, A; van Wyk, A J; Roodt, J P; Pieters, H; Herbst, C P; Otto, A C; Lötter, M G; Haasbroek, F J; Minnaar, P C; Fourie, P J

van Aswegen, A; van Wyk, A J; Roodt, J P; Pieters, H; Herbst, C P; Otto, A C; Lötter, M G; Haasbroek, F J; Minnaar, P C; Fourie, P J.

Int J Appl Radiat Isot ; 36(9): 727-32, 1985 Sep.

Article em En | MEDLINE | ID: mdl-4066067

ABSTRACT

ABSTRACT

(o)-[77Br]bromohippuran (BHIP) was developed as renal tubular function agent due to its favourable chemical and physical properties and compared to (o)-[131I]iodohippuran (IHIP). Renograms obtained from baboons were compared and absorbed radiation dose calculations performed. Although BHIP showed a delayed kidney uptake and washout pattern, good kidney clearance of the radionuclide was obtained after 30 min. Radiation dose values for BHIP were markedly lower than for IHIP indicating that larger activities of BHIP could be administered to increase counting statistics. BHIP imaging in normal volunteers did however not substantiate the favourable behaviour obtained in the primate.

Assuntos

Bromo; Ácido Iodoipúrico/análogos & derivados; Túbulos Renais/diagnóstico por imagem; Radioisótopos; Animais; Estudos de Avaliação como Assunto; Lateralidade Funcional; Rim/fisiologia; Testes de Função Renal; Papio; Cintilografia; Distribuição Tecidual; Bexiga Urinária/diagnóstico por imagem

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioisótopos / Bromo / Ácido Iodoipúrico / Túbulos Renais Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Animals Idioma: En Revista: Int J Appl Radiat Isot Ano de publicação: 1985 Tipo de documento: Article

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