Preparation and evaluation of 3-[125I]iodo-4-aminophentermine as a brain perfusion imaging agent. Comparison with labeled phentermine derivatives.
Int J Nucl Med Biol
; 12(4): 321-5, 1985.
Article
em En
| MEDLINE
| ID: mdl-4086198
ABSTRACT
A radioiodinated derivative of the anorexinergic drug phentermine was synthesized and evaluated as a potential brain imaging agent. Stoichiometric iodination of the intermediate 4-aminophentermine (AmP) gave a mixture of mono and diiodo products, while the radioiodination at the no-carrier-added (NCA) level gave 73% isolated yield of the 3-[125I]iodo-4-aminophentermine with less than 2% of the diiodo derivative. The tissue distribution of the radiochemical in rats showed that it was readily extracted by the brain followed by relatively slow clearance from that organ. However, a comparison with other labeled phentermine derivatives indicated that the total brain uptake, retention and selectivity of the new agent were poorer, probably as a result of the presence of the 4-amino substituent.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fentermina
/
Encéfalo
/
Radioisótopos do Iodo
Limite:
Animals
Idioma:
En
Revista:
Int J Nucl Med Biol
Ano de publicação:
1985
Tipo de documento:
Article