[Influence of cholestasis on enzymatic induction with phenobarbital and other enzymatic aspects: experimental studies on guinea pigs]. / Influenze della colostasi sul'induzione da fenobarbital e su altri aspetti enzimatici: osservazioni sperimentali sulla cavia
Quad Sclavo Diagn
; 10(4): 481-90, 1974 Dec.
Article
em It
| MEDLINE
| ID: mdl-4156599
ABSTRACT
Investigations in guinea pigs to evaluate interferences between cholestasis and enzymatic induction by phenobarbital, and influences that both experimental conditions exert on the levels of gamma-glutamyl transpeptidase in microsomes and other subcellular fractions, have shown that 1) cholestasis inhibits inductions of cytochrome P-450 from phenobarbital; 2) gamma-glutamyl transpeptidase is not an inducible enzyme in guinea pig; 3) rises or ferum gamma-glutanyl transpeptidase produced either by cholestasis or phenobarbital administration, are not related to an increased enzymatic synthesis in the various subcellular fractions of liver cell.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenobarbital
/
Colestase
/
Sistema Enzimático do Citocromo P-450
/
Gama-Glutamiltransferase
/
Fígado
Limite:
Animals
Idioma:
It
Revista:
Quad Sclavo Diagn
Ano de publicação:
1974
Tipo de documento:
Article