Adenosine triphosphatase. Sensitive to DDT in synapses of rat brain.
Science
; 166(3901): 121-2, 1969 Oct 03.
Article
em En
| MEDLINE
| ID: mdl-4241326
ABSTRACT
The insecticide DDT selectively inhibits the action of a Na(+), K(+), Mg(2+)-adenosine triphosphatase found in the nerve ending fraction of the rat brain. As judged by the concentrations of inhibitors that give 50 percent of enzyme inhibition, DDT was approximately 1000 times more toxic than its non-insecticidal analog, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene. The degrees of inhibition of this enzyme system by various toxic and nontoxic DDT analogs were closely related to a general toxicity in vivo of these compounds. Moreover, the extents of inhibition of this enzyme system by DDT were much higher at low temperatures, an indication of a causal relation between poisoning in vivo by DDT and the inhibition in vitro of the Na(+), K(+), Mg(2+)-adenosine triphosphatase system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Encéfalo
/
Adenosina Trifosfatases
/
DDT
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1969
Tipo de documento:
Article