Partial agonist properties and toxicity of oral oxilorphan.
J Clin Pharmacol
; 16(4): 183-7, 1976 Apr.
Article
em En
| MEDLINE
| ID: mdl-4472
ABSTRACT
Alternative pharmacologic adjuncts are needed for the management of opiate abuse. Oxilorphan, a narcotic antagonist, was studied at 5 different dose levels (1, 2, 4, 6, and 8 mg) in 30 normal subjects to determine the relation of single oral doses and toxicity. The drug causes pupillary constriction and mild central nervous system side effects (nausea, dizziness) at all doses. Mean urine volume increased (P less than 0.05) during the 12 hours after 1 and 2 mg. Oxilorphan has partial agonist properties similar to dl-cyclazocine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Morfinanos
/
Antagonistas de Entorpecentes
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Pharmacol
Ano de publicação:
1976
Tipo de documento:
Article