[Comparative evaluation of methacycline hydrochloride capsules and tablets according to their dissolubility and rate of solution]. / Sravnitel'naia otsenka kapsul i tabletok metatsiklina gidrokhlorida po raspadeamosti i skorosti rastvoreniia.
Antibiotiki
; 24(8): 604-8, 1979 Aug.
Article
em Ru
| MEDLINE
| ID: mdl-485108
ABSTRACT
Desintegration and dissolution of capsules and tablets of methacycline hydrochloride were studied. The study on solubility of methacycline hydrochliride capsules filled with methacycline granulate or powder according to the same formula showed that the rate of the antibiotic liberation from the capsules filled with the powder decreased during storage while that from the capsules filled with the granulate did not change. Investigation of the effect of the mass packing value in a drop on the antibiotic liberation from the capsules showed that an increase in the packing coefficient above 1.38 resulted in a marked decrease in the rate of methacycline liberation from the capsules filled with the granulate. No correlation between desintegration and dissolution of methacycline capsules and tablets was found.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metaciclina
Idioma:
Ru
Revista:
Antibiotiki
Ano de publicação:
1979
Tipo de documento:
Article