Hydrostatic pressure reduces synaptic efficiency by inhibiting transmitter release.
Undersea Biomed Res
; 8(3): 175-83, 1981 Sep.
Article
em En
| MEDLINE
| ID: mdl-6117144
ABSTRACT
The amplitude of post-synaptic potentials at an identified synapse in the Aplysia central nervous system can be modulated by the application of hydrostatic pressure. Postsynaptically controlled functions, including responses to acetylcholine and the time course of decay of the synaptic responses, remain unaffected by compression. In contrast, frequency facilitation and posttetanic potentiation, which result from presynaptic processes, are altered by pressure in a manner similar to that of agents that block transmitter release. It is concluded that pressure reduces synaptic efficiency by interfering with certain presynaptic mechanisms associated with transmitter release.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão
/
Sinapses
/
Neurotransmissores
/
Pressão Hidrostática
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Undersea Biomed Res
Ano de publicação:
1981
Tipo de documento:
Article