Arylsulfatase A activities in urine and tissues taken from bladder cancer patients.
Jpn J Exp Med
; 54(5): 211-6, 1984 Oct.
Article
em En
| MEDLINE
| ID: mdl-6152561
ABSTRACT
Urinary arylsulfatase A activity expressed as units/mg of urinary creatinine was significantly increased in bladder cancer patients, but not in patients with other genitourinary tract disorders, such as cystitis, urethritis and prostatic cancer, nor in patients with non-urological malignant diseases. The urinary enzyme activity was positively correlated with the stage of the bladder cancer, while post surgical follow-up revealed a marked decrease of the activity. Arylsulfatase A activity was also shown to be higher in malignant than in normal bladder tissue, demonstrating the activity to be a function of the grade of the tumor. Furthermore, the isoelectric point (pI 5.2-5.3) of the tissue enzyme in the bladder tumor coincided with that of the urine enzyme from the same cancer patients; the pI of the enzyme in urine from normal subjects was 4.7. These results suggest that most of the urinary arylsulfatase A in bladder cancer originates from tumor tissue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfatases
/
Neoplasias da Bexiga Urinária
/
Cerebrosídeo Sulfatase
Limite:
Humans
/
Male
Idioma:
En
Revista:
Jpn J Exp Med
Ano de publicação:
1984
Tipo de documento:
Article