Hormonal and blood pressure changes during converting enzyme inhibition by teprotide.
Postgrad Med J
; 57(667): 283-8, 1981 May.
Article
em En
| MEDLINE
| ID: mdl-6170971
ABSTRACT
Changes induced by i.v. and subcutaneous teprotide in plasma renin, angiotensin I, angiotensin II, aldosterone and bradykinin were studied in a renal transplant patient with severe high renin hypertension, before and after trinephrectomy. The immediate reduction in BP produced by teprotide was not solely attributable to the inhibition of conversion of angiotensin I to angiotensin II, because there was also a transient increase in serum bradykinin; however, the prolonged antihypertensive effect of teprotide appeared independent of bradykinin. After trinephrectomy, teprotide lowered systolic BP but had no significant effect on diastolic BP or plasma bradykinin. beta-Blockade prevented the secondary increase in plasma renin which followed teprotide, thereby potentiating its anti-hypertensive effect.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Inibidores da Enzima Conversora de Angiotensina
/
Teprotida
/
Renina
/
Hipertensão Renal
Limite:
Female
/
Humans
Idioma:
En
Revista:
Postgrad Med J
Ano de publicação:
1981
Tipo de documento:
Article