Nephronophthisis with massive proteinuria.
Am J Kidney Dis
; 2(6): 640-4, 1983 May.
Article
em En
| MEDLINE
| ID: mdl-6189393
ABSTRACT
A 23-year-old male whose uncle died of nephronophthisis, and whose pathology is also discussed, presented with 5 g of protein in a 24-hour urine collection. Nephrogenic diabetes insipidus and salt wasting were present in addition to azotemia. Characterization of the proteinuria, including elevated alpha globulins by electrophoresis and markedly elevated urinary beta-microglobulins by radioimmunoassay (49.55 mg/L) indicated predominantly tubular proteinuria. A percutaneous renal biopsy showed normal glomeruli, interstitial inflammation and fibrosis, and tubular atrophy. Electron microscopy revealed notable alterations of the tubular basement membrane.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteinúria
/
Doenças Renais Císticas
/
Nefropatias
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Kidney Dis
Ano de publicação:
1983
Tipo de documento:
Article