Inhibin interaction with LHRH receptors at the pituitary level.
Arch Androl
; 8(3): 185-8, 1982 May.
Article
em En
| MEDLINE
| ID: mdl-6285843
ABSTRACT
In order to investigate whether inhibin could modulate the action of luteinizing hormone releasing hormone (LHRH), the in vitro effect of inhibin of LHRH bindings to the pituitaries from intact adult male rats was studied. The inhibin preparations suppressed the binding of labeled LHRH to pituitary receptors in a dose-related manner. In vivo administration of inhibin decreased the pituitary LHRH receptor concentration, with an apparent increase in the affinity of these receptors. A dose-related decrease was observed in serum follicle stimulating hormone (FSH) levels in the same group whereas the serum luteinizing hormone (LH) levels remained unaltered. There may be a direct action of inhibin at the pituitary level to suppress FSH levels specifically.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipófise
/
Hormônios Testiculares
/
Proteínas
/
Receptores de Superfície Celular
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Arch Androl
Ano de publicação:
1982
Tipo de documento:
Article