Chlorphentermine-induced alterations in the lungs of vitamin E-deficient and -supplemented rats: quantitative ultrastructural analysis of Type II Cell response.
Exp Mol Pathol
; 39(1): 80-8, 1983 Aug.
Article
em En
| MEDLINE
| ID: mdl-6307743
ABSTRACT
Response of alveolar Type II (T-II) cells of male Sprague-Dawley weanling rats maintained on vitamin E (VE)-deficient and -supplemented diets to chlorphentermine (CP) treatment was evaluated. Ultrastructural and quantitative procedures were used to assess the T-II cell-drug interaction. Subjective examination of photomicrographs revealed numerous disrupted surfactant lamellar bodies in the CP-treated animals, as compared to fewer in controls. In addition, an unusual amorphous material was associated with these cells in drug-treated animals. Quantitative assessment confirmed the above subjective impression and revealed an increase in the size of T-II cells in treated rats. Morphometric evaluation showed that CP treatment significantly altered the volume density of cytoplasm, mitochondria, and rough endoplasmic reticulum (RER). Furthermore, a significant interaction between the diet and treatment with respect to volume fractions of mitochondria, RER, and Golgi complex was observed. The present study indicates that cytoplasmic components in T-II cells are altered as a result of CP treatment and that VE status of the animals influences the nature and extent of these alterations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fentermina
/
Alvéolos Pulmonares
/
Vitamina E
/
Deficiência de Vitamina E
/
Clorfentermina
Limite:
Animals
Idioma:
En
Revista:
Exp Mol Pathol
Ano de publicação:
1983
Tipo de documento:
Article