Influence of the corneal epithelium on the efficacy of topical antifungal agents.
Invest Ophthalmol Vis Sci
; 25(7): 855-9, 1984 Jul.
Article
em En
| MEDLINE
| ID: mdl-6329991
ABSTRACT
A model of deep stromal Candida albicans infection was established by injecting 25 microliters of a suspension containing 5 X 10(9) colony forming units/ml of the yeast into corneas of pigmented rabbits. In this model, the infection lasts for more than 8 days. Using quantitative techniques, the authors compared the efficacy of six topical antifungal agents in the presence of an intact epithelium and in corneas debrided of epithelium. In corneas debrided on a daily basis, the polyenes (amphotericin B 0.15% and 0.075% and natamycin 5%) exhibited a significant antifungal effect. When the epithelium was left intact, 5% natamycin and 0.075% amphotericin B were without effect, while the efficacy of the 0.15% preparation of amphotericin B was much reduced. Removal of the epithelium appeared to affect adversely the efficacy of flucytosine. The imidazoles were not efficacious in this model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córnea
/
Antifúngicos
Limite:
Animals
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Ano de publicação:
1984
Tipo de documento:
Article