Binding of (-) deprenyl to serum proteins.

ABSTRACT

14C-Deprenyl binding to serum proteins has been investigated using equilibrium dialysis and gel chromatography. Experiments in the equilibrium dialysis cells were performed both for binding of deprenyl to the serum proteins and the dissociation of the previously serum bound deprenyl. Comparative investigations were made with substance E, this reference compound showed reversible binding contrary to deprenyl that remained partially irreversibly bound to the serum proteins even in such conditions when substance E became totally released.