Interferon fever: absence of human leukocytic pyrogen response to recombinant alpha-interferon.
J Leukoc Biol
; 36(1): 17-25, 1984 Jul.
Article
em En
| MEDLINE
| ID: mdl-6588130
ABSTRACT
A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocytic pyrogen. This result suggests that interferon may cause fever by a novel mechanism not dependent on leukocytic pyrogen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirogênios
/
Monócitos
/
Interferon Tipo I
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
1984
Tipo de documento:
Article