A rapid and highly sensitive solid-phase radioassay for plasminogen activators.
Thromb Res
; 31(2): 269-77, 1983 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-6685354
ABSTRACT
A rapid and highly sensitive solid-phase radioassay for the measurement of plasminogen activators is presented. The method employs a convenient and stable 125I-fibrinogen-latex bead product and can reproducibly detect 0.25 milli Ploug units/ml of urokinase. This represents a 100-fold increase in sensitivity over previously published radioisotopic solid-phase technique and a 120-fold increase over the sensitivity of the fibrin plate method. Since the assay can readily detect plasminogen activator levels in euglobulin solutions prepared from pre- and post-venous occlusion plasma, it may be useful for rapidly detecting and monitoring the fibrinolytic potential of patients predisposed to thromboembolic disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativadores de Plasminogênio
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Thromb Res
Ano de publicação:
1983
Tipo de documento:
Article