Effects of Lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
Oncology
; 41 Suppl 1: 15-29, 1984.
Article
em En
| MEDLINE
| ID: mdl-6717891
ABSTRACT
Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both 'in vitro' and 'in vivo'. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine's effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Carcinoma de Ehrlich
/
Indazóis
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Oncology
Ano de publicação:
1984
Tipo de documento:
Article