[Effects of phosphatidylserine in an experimental model of generalized epilepsy]. / Effetti della fosfatidilserina in un modello sperimentale di epilessia generalizzata.
Riv Neurol
; 54(2): 128-38, 1984.
Article
em It
| MEDLINE
| ID: mdl-6740167
ABSTRACT
The possible antiepileptic activity of PS has been tested in a model of generalized epilepsy induced by penicillin in the cat. In acute experiments, topical application to the cortex of PS (from 20 mg/ml to 50 mg/ml) produced a reverse in the polarity of the spike and wave complex and, sometimes, a decrease in the voltage as well as a morphological deformation of s-w bursts. Chronic intraperitoneal administration of PS induced a decrease of the epileptic burst frequency. The effect was already apparent after 14 days and of greater extent after 21 days. Finally the antiepileptic effect of 0,2-0,5 mg/Kg diazepam, given in a single dose during the maximal epileptic activity resulted markedly reinforced in animals chronically treated with PS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilserinas
/
Epilepsia
Limite:
Animals
Idioma:
It
Revista:
Riv Neurol
Ano de publicação:
1984
Tipo de documento:
Article