Elimination of phenoperidine in liver disease.
Br J Anaesth
; 56(8): 843-7, 1984 Aug.
Article
em En
| MEDLINE
| ID: mdl-6743448
ABSTRACT
The disposition and elimination of phenoperidine was studied in five normal subjects, and in six patients with hepatic disease. Plasma concentrations of phenoperidine were generally higher in patients with hepatic dysfunction. Secondary peaks were observed between 15 and 105 min (particularly in patients with liver disease). In the patients the terminal half-life of phenoperidine was prolonged by approximately 50%, mainly because of a decrease in the clearance of the drug. There was little or no change in the total apparent volume of distribution. However, the differences between normal subjects and patients with hepatic disease were not statistically significant. The results suggest that slight or moderate impairment of hepatic function does not significantly affect the kinetics of the drug, and that modification of its dosage may not be required.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenoperidina
/
Hepatopatias
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Br J Anaesth
Ano de publicação:
1984
Tipo de documento:
Article